Dimerix has used its Receptor-HIT technology to identify a new treatment (DMX-200) that may transform the lives of patients with kidney disease.
Phase 2a Study
In 2017, Dimerix completed its first Phase 2a study in patients with a range of Chronic Kidney Diseases. All trial endpoints were achieved and DMX-200 was determined to be safe and tolerable. In a subsequent sub-group analysis of these results, statistically and clinically significant efficacy signals were seen in patients with diabetes. The common clinical marker for progression of kidney disease is an increase in protein in the urine (known as proteinuria), and a significant reduction in proteinuria demonstrates the progression of kidney failure as been slowed.
Irbesartan, the current standard of care treatment for kidney disease which has been on the market since 2001, has been shown to reduce proteinuria levels by 24% in type 2 diabetics. DMX-200, when administered to patients already taking irbesartan, reduced proteinuria levels by a further 36%. To be clear, this 36% is in addition to the 24% already seen from irbesartan and may result in delaying kidney failure and dialysis, compared to taking irbesartan alone. The compelling results from this study prompted the decision to raise capital in early 2018 towards funding two different clinical trials in 2018: one for patients with Diabetic Kidney Disease; and the second for patients with another form of inflammatory kidney disease, Focal Segmental Glomerulosclerosis (or FSGS).