Publications

Links to a selection of publications from Associate Professor Kevin Pfleger’s research group are provided below:

Ayoub MA, Pfleger KDG. 2010. Recent advances in bioluminescence resonance energy transfer technologies to study GPCR heteromerization. Current Opinion in Pharmacology 10:44-52. [NCBI PubMed Entry]

Kocan M, See HB, Sampaio NG, Eidne KA, Feldman BJ, Pfleger KDG. 2009. Agonist-independent interactions between b-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis. Molecular Endocrinology 23:559-571. [NCBI PubMed Entry]

Ferré S, Baler R, Bouvier M, Caron MG, Devi LA, Durroux T, Fuxe K, George SR, Javitch JA, Lohse MJ, Mackie K, Milligan G, Pfleger KDG, Pin JP, Volkow N, Waldhoer M, Woods AS, Franco R. 2009. Building a new conceptual framework for receptor heteromers. Nature Chemical Biology 5:131-134. [NCBI PubMed Entry]

Pfleger KDG, Pawson AJ, Millar RP. 2008. Changes to gonadotropin-releasing hormone (GnRH) receptor extracellular loops differentially affect GnRH analog binding and activation: evidence for distinct ligand-stabilized receptor conformations. Endocrinology 149:3118-3129. [NCBI PubMed Entry]

Kocan M, See HB, Seeber RM, Eidne KA, Pfleger KDG. 2008. Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells. Journal of Biomolecular Screening 13:888-898. [NCBI PubMed Entry]

Dalrymple MB, Pfleger KDG, Eidne KA. 2008. G protein-coupled receptor dimers: Functional consequences, disease states and drug targets. Pharmacology & Therapeutics 118:359-371. [NCBI PubMed Entry]

Pfleger KDG, Eidne KA. 2006. Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET). Nature Methods 3:165-174. [NCBI PubMed Entry]

Pfleger KDG, Seeber RM, Eidne KA. 2006. Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions. Nature Protocols 1:336-344. [NCBI PubMed Entry]

Pfleger KDG, Dromey JR, Dalrymple MB, Lim EML, Thomas WG, Eidne KA. 2006. Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein-protein interactions in live cells. Cellular Signalling 18:1664-1670. [NCBI PubMed Entry]

Pfleger KDG, Eidne KA. 2005. Monitoring the formation of dynamic G-protein-coupled receptor-protein complexes in living cells. Biochemical Journal 385:625-637. [NCBI PubMed Entry]